3/1/2023 0 Comments Photodesk beta 5![]() Secondary endpoints included post-meal glucagon, insulin secretion rate, gastric emptying, and food intake. The primary endpoint of this four-week study compared the effect of exenatide and sitagliptin on 2-hour post-meal glucose. "Patients on exenatide experienced significantly lower post-meal glucose levels, improved measures of beta cell function and decreased food intake." Exenatide works directly on the GLP-1 receptor, whereas sitagliptin indirectly affects GLP-1 levels," said Ralph DeFronzo, M.D., professor of medicine and chief of the diabetes division at the University of Texas Health Science Center in San Antonio and a clinical trial investigator on this study. "There has been some confusion in the marketplace about the therapeutic differences between exenatide and sitagliptin, and data from this first head-to-head study showed a clear difference in the MOAs and resultant short-term clinical effects between these two agents. The study will also be published in the peer-reviewed journal, Current Medical Research and Opinion. The findings were presented at the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Rome, Italy. This is the first reported head-to-head study directly comparing the therapeutic mechanisms of action (MOA) of exenatide and sitagliptin. ![]() Additionally, patients treated with exenatide reduced post-meal glucagon, showed more efficient use of their body's own insulin and decreased their food intake when compared to sitagliptin. (Nasdaq: AMLN) and Eli Lilly and Company (NYSE: LLY) today announced results from a randomized, double-blind, cross-over, four-week head-to-head study demonstrating that BYETTA(R) (exenatide) injection, a GLP-1 receptor agonist, provided significantly lower glucose levels in the post-meal setting when compared to Januvia(TM) (sitagliptin), a DPP-4 inhibitor. Patients Taking Exenatide Also Reduced Food IntakeĪmylin Pharmaceuticals, Inc. ![]()
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